Посттравматическое стрессовое расстройство: от нейронных сетей к омикс-механизмам и персонализированной терапии
10 марта 2026
Посттравматическое стрессовое расстройство: от нейронных сетей к омикс-механизмам и персонализированной терапии
Литература
- Tadesse Tarik Tamir, Berhan Tekeba, Enyew Getaneh Mekonen, Deresse Abebe Gebrehana, Alebachew Ferede Zegeye. (2025). Shadows of trauma: an umbrella review of the prevalence and risk factors of post-traumatic stress disorder in children and adolescents. Child Adolesc Psychiatry Ment Health. 19;
- Ronald C. Kessler, Sergio Aguilar-Gaxiola, Jordi Alonso, Corina Benjet, Evelyn J. Bromet, et. al.. (2017). Trauma and PTSD in the WHO World Mental Health Surveys. European Journal of Psychotraumatology. 8;
- Rustad S.A. (2024) Conflict Trends: A Global Overview, 1946–2023. PRIO Paper;
- Fiona Charlson, Mark van Ommeren, Abraham Flaxman, Joseph Cornett, Harvey Whiteford, Shekhar Saxena. (2019). New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis. The Lancet. 394, 240-248;
- American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders — American Psychiatric Association, 2013;
- Jessica E. Lambert, Jessica Holzer, Amber Hasbun. (2014). Association Between Parents’ PTSD Severity and Children's Psychological Distress: A Meta‐Analysis. Journal of Traumatic Stress. 27, 9-17;
- David F. Tolin, Edna B. Foa. (2006). Sex differences in trauma and posttraumatic stress disorder: A quantitative review of 25 years of research.. Psychological Bulletin. 132, 959-992;
- Ahmed A. Moustafa, Mark W. Gilbertson, Scott P. Orr, Mohammad M. Herzallah, Richard J. Servatius, Catherine E. Myers. (2013). A model of amygdala–hippocampal–prefrontal interaction in fear conditioning and extinction in animals. Brain and Cognition. 81, 29-43;
- Fredrik Åhs, Philip A. Kragel, David J. Zielinski, Rachael Brady, Kevin S. LaBar. (2015). Medial prefrontal pathways for the contextual regulation of extinguished fear in humans. NeuroImage. 122, 262-271;
- Young-Rae Kim, Moonhyung Lee, Man S. Kim. (2025). Astrocytes in Fear Memory Processing: Molecular Mechanisms Across the Amygdala–Hippocampus–Prefrontal Cortex Network. Cells. 14, 1444;
- Lisa M Shin, Israel Liberzon. (2010). The Neurocircuitry of Fear, Stress, and Anxiety Disorders. Neuropsychopharmacol. 35, 169-191;
- . (1995). MRI-based measurement of hippocampal volume in patients with combat- related posttraumatic stress disorder. AJP. 152, 973-981;
- Tamara V. Gurvits, Martha E. Shenton, Hiroto Hokama, Hirokazu Ohta, Natasha B. Lasko, et. al.. (1996). Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biological Psychiatry. 40, 1091-1099;
- M. B. STEIN, C. KOVEROLA, C. HANNA, M. G. TORCHIA, B. McCLARTY. (1997). Hippocampal volume in women victimized by childhood sexual abuse. Psychol. Med.. 27, 951-959;
- Gerardo Villarreal, Derek A Hamilton, Helen Petropoulos, Ira Driscoll, Laura M Rowland, et. al.. (2002). Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder. Biological Psychiatry. 52, 119-125;
- Thomas W. Freeman, David Cardwell, Craig N. Karson, Richard A. Komoroski. (1998). In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subjects with combat‐related posttraumatic stress disorder. Magnetic Resonance in Med. 40, 66-71;
- Gerardo Villarreal, Helen Petropoulos, Derek A Hamilton, Laura M Rowland, William P Horan, et. al.. (2002). Proton Magnetic Resonance Spectroscopy of the Hippocampus and Occipital White Matter in PTSD: Preliminary Results. Can J Psychiatry. 47, 666-670;
- Kerry. J. Ressler, Sabina Berretta, Vadim Y. Bolshakov, Isabelle M. Rosso, Edward G. Meloni, et. al.. (2022). Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 18, 273-288;
- Mohammed R. Milad, Gregory J. Quirk. (2012). Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress. Annu. Rev. Psychol.. 63, 129-151;
- Yehuda R. (2001). Biology of posttraumatic stress disorder. J. Clin. Psychiatry. 62, 41–46;
- Jiawei Wang, Yujing Liu, Hongyu Li, Tuan P. Nguyen, John Lee Soto-Vargas, et. al.. (2025). A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder. Genome Med. 17;
- Olga Babaev, Carolina Piletti Chatain, Dilja Krueger-Burg. (2018). Inhibition in the amygdala anxiety circuitry. Exp Mol Med. 50, 1-16;
- Lydiard R.B. (2003). The role of GABA in anxiety disorders. J. Clin. Psychiatry. 64, 21–27;
- Ahyeon Hwang, Mario Skarica, Siwei Xu, Jensine Coudriet, Che Yu Lee, et. al.. (2025). Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Nature. 643, 744-754;
- Hongyu Li, Yujing Liu, Yiming Shi, Jiawei Wang, Tuan P. Nguyen, et. al.. (2025). Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain. Biological Psychiatry;
- Naoko H. Tomioka, Hiroki Yasuda, Hiroyuki Miyamoto, Minoru Hatayama, Naoko Morimura, et. al.. (2014). Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures. Nat Commun. 5;
- Tevye Jason Stachniak, Emily Lauren Sylwestrak, Peter Scheiffele, Benjamin J. Hall, Anirvan Ghosh. (2019). Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons. J. Neurosci.. 39, 4461-4474;
- Hayato Matsunaga, Jun Aruga. (2021). Trans-Synaptic Regulation of Metabotropic Glutamate Receptors by Elfn Proteins in Health and Disease. Front. Neural Circuits. 15;
- Lorena Varela-Nallar, Iván E. Alfaro, Felipe G. Serrano, Jorge Parodi, Nibaldo C. Inestrosa. (2010). Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses. Proc. Natl. Acad. Sci. U.S.A.. 107, 21164-21169;
- Eva Ramos-Fernández, Macarena S. Arrázola, Carolina A. Oliva, Sebastián B. Arredondo, Lorena Varela-Nallar, Nibaldo C. Inestrosa. (2021). Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase. Sci Rep. 11;
- Hana Yeh, Maya E. Woodbury, Kaitlin L. Ingraham Dixie, Tsuneya Ikezu, Seiko Ikezu. (2023). Microglial WNT5A supports dendritic spines maturation and neuronal firing. Brain, Behavior, and Immunity. 107, 403-413;
- Xinzhao Chen, Yifan Jiang, Jiayu Wang, Yishu Liu, Menglei Xiao, et. al.. (2020). Synapse impairment associated with enhanced apoptosis in post‐traumatic stress disorder. Synapse. 74;
- Jonathan J. Sabbagh, Ricardo A. Cordova, Dali Zheng, Marangelie Criado-Marrero, Andrea Lemus, et. al.. (2018). Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD. ACS Chem. Biol.. 13, 2288-2299;
- Alexander S. Häusl, Lea M. Brix, Jakob Hartmann, Max L. Pöhlmann, Juan-Pablo Lopez, et. al.. (2021). The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice. Mol Psychiatry. 26, 3060-3076;
- Anthony S Zannas, Tobias Wiechmann, Nils C Gassen, Elisabeth B Binder. (2016). Gene–Stress–Epigenetic Regulation of FKBP5: Clinical and Translational Implications. Neuropsychopharmacol. 41, 261-274;
- Jing Zhang, Alfred P. Kaye, Jiawei Wang, Matthew J. Girgenti. (2021). Transcriptomics of the depressed and PTSD brain. Neurobiology of Stress. 15, 100408;
- Julie Rendum Klaeth, Andreas Gjerde Jensen, Trude Julie Brynhildsvoll Auren, Stian Solem. (2024). 12-month follow-up of intensive outpatient treatment for PTSD combining prolonged exposure therapy, EMDR and physical activity. BMC Psychiatry. 24;
- Lisa D Moore, Thuc Le, Guoping Fan. (2013). DNA Methylation and Its Basic Function. Neuropsychopharmacol. 38, 23-38;
- Kevin J. Dudley, Xiang Li, Michael S. Kobor, Tod E. Kippin, Timothy W. Bredy. (2011). Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders. Neuroscience & Biobehavioral Reviews. 35, 1544-1551;
- Divya Mehta, Olivia Miller, Dagmar Bruenig, Georgina David, Jane Shakespeare‐Finch. (2020). A Systematic Review of DNA Methylation and Gene Expression Studies in Posttraumatic Stress Disorder, Posttraumatic Growth, and Resilience. Journal of Traumatic Stress. 33, 171-180;
- Jacob Peedicayil. (2011). Epigenetic management of major psychosis. Clin Epigenet. 2, 249-256;
- Lap Ho, Patricia A. Bloom, Joan G. Vega, Shrishailam Yemul, Wei Zhao, et. al.. (2016). Biomarkers of Resilience in Stress Reduction for Caregivers of Alzheimer’s Patients. Neuromol Med. 18, 177-189;
- Christiaan H. Vinkers, Elbert Geuze, Sanne J. H. van Rooij, Mitzy Kennis, Remmelt R. Schür, et. al.. (2021). Successful treatment of post-traumatic stress disorder reverses DNA methylation marks. Mol Psychiatry. 26, 1264-1271;
- Sarah Wilker, Vanja Vukojevic, Anna Schneider, Anett Pfeiffer, Stefan Inerle, et. al.. (2023). Epigenetics of traumatic stress: The association of NR3C1 methylation and posttraumatic stress disorder symptom changes in response to narrative exposure therapy. Transl Psychiatry. 13;
- Candace R. Lewis, Joseph Tafur, Sophie Spencer, Joseph M. Green, Charlotte Harrison, et. al.. (2023). Pilot study suggests DNA methylation of the glucocorticoid receptor gene (NR3C1) is associated with MDMA-assisted therapy treatment response for severe PTSD. Front. Psychiatry. 14;
- Elisabeth Hummel, Magdeldin Elgizouli, Maurizio Sicorello, Elsa Leitão, Jasmin Beygo, et. al.. (2022). No evidence for intervention-associated DNA methylation changes in monocytes of patients with posttraumatic stress disorder. Sci Rep. 12;
- Alicia K. Smith, Karen N. Conneely, Varun Kilaru, Kristina B. Mercer, Tamara E. Weiss, et. al.. (2011). Differential immune system DNA methylation and cytokine regulation in post‐traumatic stress disorder. American J of Med Genetics Pt B. 156, 700-708;
- D. Mehta, D. Bruenig, T. Carrillo‐Roa, B. Lawford, W. Harvey, et. al.. (2017). Genomewide
DNA methylation analysis in combat veterans reveals a novel locus forPTSD . Acta Psychiatr Scand. 136, 493-505; - the Traumatic Stress Brain Study Group, Mark W. Logue, Mark W. Miller, Erika J. Wolf, Bertrand Russ Huber, et. al.. (2020). An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. Clin Epigenet. 12;
- B P F Rutten, E Vermetten, C H Vinkers, G Ursini, N P Daskalakis, et. al.. (2018). Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry. 23, 1145-1156.
